Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

Lambourne L, Mattioli K, Santoso C, Sheynkman G, Inukai S, Kaundal B, Berenson A, Spirohn-Fitzgerald K, Bhattacharjee A, Rothman E, Shrestha S, Laval F, Carroll BS, Plassmeyer SP, Emenecker RJ, Yang Z, Bisht D, Sewell JA, Li G, Prasad A, Phanor S, Lane R, Moyer DC, Hunt T, Balcha D, Gebbia M, Twizere J, Hao T, Holehouse AS, Frankish A, Riback JA, Salomonis N, Calderwood MA, Hill DE, Sahni N, Vidal M, Bulyk ML, Fuxman Bass JI
April 2025
Cite Source Document

Abstract

Systematic comparison of transcription factor isoforms revealing widespread divergence in DNA binding, protein interactions, and regulatory activity, often linked to intrinsically disordered regions and misregulated in tumors.

Type
Journal article
Publication
Molecular Cell
Transcription Factors Isoforms Gene Regulation
Kaia Mattioli
Kaia Mattioli
Assistant Professor