Article-Journal

Beyond the gene: Decoding alternative isoforms
An invited review on how alternative isoforms expand the functional output of the genome and why they matter in disease.
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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Systematic comparison of transcription factor isoforms revealing widespread divergence in DNA binding, protein interactions, and regulatory activity, often linked to intrinsically disordered regions and misregulated in tumors.
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AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
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Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers
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Determinants of gastric cancer immune escape identified from non-coding immune-landscape quantitative trait loci
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Systematic characterization of regulatory variants of blood pressure genes
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Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC
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Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy
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Genome-wide CRISPR interference screen identifies lncRNA loci required for pluripotency and differentiation
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Cis and trans effects differentially contribute to the evolution of promoters and enhancers
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