Mattioli Lab

The Mattioli Lab is officially opening October 1, 2026 at the University of Colorado Denver!

Mon, 01 Jun 2026 00:00:00 +0000

The Mattioli Lab is launching in 2026 and is recruiting at all levels — postdocs, graduate students, and undergraduates. If you’re excited about RNA isoforms, functional genomics, and cancer, please get in touch.

Join us

Thu, 01 Jan 2026 00:00:00 +0000

People

Thu, 01 Jan 2026 00:00:00 +0000

Research

Thu, 01 Jan 2026 00:00:00 +0000

Beyond the gene: Decoding alternative isoforms

Mon, 01 Dec 2025 00:00:00 +0000

Invited review.

Invited review out in Trends in Genetics

Mon, 01 Dec 2025 00:00:00 +0000

Our invited review, “Beyond the gene: Decoding alternative isoforms,” is published in Trends in Genetics.

Kaia presented at the Rules of Protein–DNA Recognition meeting in Cancún

Wed, 15 Oct 2025 00:00:00 +0000

Kaia presented work on transcription factor isoform diversity at the Rules of Protein–DNA Recognition meeting in Cancún, Mexico.

Transcription factor isoform study published in Molecular Cell

Tue, 01 Apr 2025 00:00:00 +0000

Our study showing widespread variation in the molecular interactions and regulatory properties of transcription factor isoforms is published in Molecular Cell.

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

Tue, 01 Apr 2025 00:00:00 +0000

AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

Tue, 01 Oct 2024 00:00:00 +0000

Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers

Thu, 01 Aug 2024 00:00:00 +0000

Determinants of gastric cancer immune escape identified from non-coding immune-landscape quantitative trait loci

Wed, 01 May 2024 00:00:00 +0000

Systematic characterization of regulatory variants of blood pressure genes

Mon, 01 May 2023 00:00:00 +0000

Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC

Sat, 01 Apr 2023 00:00:00 +0000

Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy

Tue, 01 Mar 2022 00:00:00 +0000

Genome-wide CRISPR interference screen identifies lncRNA loci required for pluripotency and differentiation

Mon, 01 Nov 2021 00:00:00 +0000

Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Sat, 01 Aug 2020 00:00:00 +0000

Resolving mechanisms of immune-mediated disease in primary CD4 T cells

Wed, 01 Apr 2020 00:00:00 +0000

High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue-specificity

Fri, 01 Mar 2019 00:00:00 +0000

Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs

Sun, 01 Jan 2017 00:00:00 +0000